Choukroun’s PRF treatment in implant dentistry can help achieving accelerated wound healing and tissue regeneration -soft and hard tissue-, increased stimulation of osteogenesis and new blood vessel formation.

Advantages of PRF treatment:

  • 100% autologous/derived from the patients’ own blood
  • PRF technology is readily available
  • easy to prepare and use
  • can be produced immediately at chairside
  • widely applicable in dentistry
  • financially realistic for both the patient and the clinician
  • no risk of a rejection reaction (no foreign body response)

Physical application

PRF (A-PRF or L-PRF) can either be used as

  • a clot
  • membrane
  • injectable liquid (i-PRF)
  • plug, or
  • cut up in fragments.

PRF can either be applied in stand-alone, additive, or in combination therapies.



Stand-alone therapies

Typical stand-alone therapies include using the fibrin plug or membrane as a filler material in extraction sockets to prevent complications and to enhance socket healing (Choukroun, et al., 2006).



PRF can also be used as a protective barrier membrane to seal off and promote healing of oroantral communications following extractions; to close a palatal connective tissue harvesting site; or as sole grafting material in sinus floor elevations.

Additive therapies

PRF (membrane or liquid) can be added or mixed to bone substitutes such as xenograft or biphasic calcium phosphate (BCP) to enhance the formation of new bone.


Combination therapies

The membrane is often used in combination with other biomaterials in bone augmentation and grafting sites as a graft material or barrier membrane (Hamzacebi, et al., 2015).

The purpose of PRF is to activate and facilitate the healing and regenerative capacity of the host tissue, by providing a strong fibrin scaffold, major growth factors, and allowing space for tissue regeneration.

Using PRF as a protective barrier on bone graft sites helps avoid perforations of the weakened gingival tissues and prevent associated contamination of the bone graft below.


The use of Choukroun’s PRF treatment enables local delivery of a fibrin matrix, cells, growth factors, and proteins that provide unique biological properties and cues for promoting new blood vessel formation, and accelerating wound healing and tissue regeneration, while at the same time reducing adverse events.

The benefits of PRF treatment in wound and bone healing, its antibacterial and antihemorrhagic effects, the low risks with its use, and the availability of easy and low-cost preparation methods should encourage more clinicians to adopt this technology in their practices for the benefit of their patients



CLICK on the link below to find out more about the PRF course

PRF 2 day


Drs. Johan Hartshorne and Howard Gluckman: A comprehensive clinical review of platelet-rich fibrin (PRF) and its role in promoting tissue healing and regeneration: part 2

Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:299-303.

Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e56-e60

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